Iron oxide magnetic nanoparticles are biocompatible agents with wide-ranging applications in biomedicine, including targeted photo- and magneto-thermal cancer therapy, drug delivery, and MRI contrast enhancement. Multicore iron oxide nanoflowers (IONFs) in particular have shown utility as efficient heat mediators for diagnosing and treating obstructive conditions, such as blood clots and thromboembolism. However, the impact of dosage and structural variations on their biocompatibility and their susceptibility to modifications within the body is poorly understood. Such knowledge is essential in assessing toxicity and optimizing effectiveness in theranostic applications.
Recently, researchers from ETH Zurich, Université Paris-Saclay, Paris-Sorbonne University and the University of Greifswald led by Monika Colombo and Ali Abou-Hassan presented a multiscale physicochemical approach to evaluate the interaction of IONFs with human blood platelets, assessing primary cytocompatibility, relaxation properties, and morphological changes due to IONF exposure.
The authors found a direct correlation between IONF concentration and platelet activation, with higher concentrations leading to a growth in platelet subpopulations and pseudopod formation. MRI and microscopy measurements also indicated data dose-dependent interactions between IONFs and platelets. Taken together, these findings align with biological data, supporting the theranostic potential of IONFs for thromboembolic disease management and offering key insights into IONF-platelet interactions.
Written by Suyash Damir
Read the published article here.
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